ABSTRACT
Fifty neonates and infants were collected from Dermatology, Pediatric and Emergency departments of the Alexandria Main University and Children's Hospitals. They were classified into five groups according to their age. Eccrine sweat glands function was studied using a starch iodine test [Wada's test] for all the cases. Histologic [H and E] and ultrastructural studies were done for some cases representing the studied groups. Starch iodine test [Wada's] was found significantly low in the first age group [less than one week age] compared to all the other older age groups [F=8.5128 and P=<0.01] with linear relationship among all the group in relation to their age. Histological results of studied cases showed primitive and immature eccrine sweat gland acini with non canalized ducts in younger age groups [less than 7 days of age], starting maturation of acini and ducts in slightly older age group [one to 4 weeks age] and fully mature acini and ducts among all the older groups [older than one month age]. Electron microscopic studies showed similar findings with immaturity of cells, nuclei and cell organoids in younger age groups [less than 7 days], starting maturation of cells and early appearance of cell organoids in slightly older age [one to four weeks age], and complete maturation of cell structure, nuclei and full appearance of cell organoids in all the older age groups [one month and more]. Clinical, histological and ultrastructural results of this study can support the suggestion that during new born and early infancy periods, sweat glands are immature and poorly functioning and with progress of age they attain full maturation and complete function
Subject(s)
Humans , Male , Female , Microscopy, Electron , InfantABSTRACT
Intracavernosal pharmacotherapy has revolutionized treatment of erectile dysfunction. In this study, 84 patients with impotence were classified into two groups [42 for each] and they were injected with PGE1 alone [20 ug/ml] and "3Ps" solution containing papaverine [12 mg/ml], PGE1 [9 ug/ml] and phentolamine [1 mg/ml] in a double blind-crossover maneuver of treatment. Prostaglandin El alone induced full rigid-satisfactory erection in 71.4% of treated patients, with mean time of latency between injection of the drug and start of tumescence of 14 minutes and average duration of erection of 131.8 minutes. In the "3Ps" solution, full rigid-satisfactory erection was obtained in 90.5% of the treated cases, with a latency period of 8.4 minutes and duration of erection of 182.8 minutes. Penile self stimulation was required in the PGE1-alone treated group in 76.2% of cases, while it was only required in 52.4% of cases in the "3Ps" treated group of patients. Side effects of both drug regimens were minimal and not severe, and they were less frequently occurring in the "3Ps" solution treated group of patients. It was concluded that the use of PGE1 in combination with other vasoactive drugs makes the combination more durable in action and with less side effects than if the drug was used alone. Also, the dosage required for each vasoactive agent is less than that if each drug is used alone